A Research Agenda for Malaria Eradication: Basic Science and Enabling Technologies

被引：35

作者：

Baum, Jake ^{[1
]}

Billker, Oliver ^{[2
]}

Bousema, Teun ^{[3
]}

Dinglasan, Rhoel ^{[4
]}

McGovern, Victoria ^{[5
]}

Mota, Maria M. ^{[6
]}

Mueller, Ivo ^{[7
]}

Sinden, Robert ^{[8
]}

机构：

[1] Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia

[2] Wellcome Trust Sanger Inst, London, England

[3] London Sch Hyg & Trop Med, London WC1, England

[4] Johns Hopkins Malaria Res Inst, Baltimore, MD USA

[5] Burroughs Wellcome Fund, Raleigh, NC USA

[6] Inst Med Biol Mol, Lisbon, Portugal

[7] Papua New Guinea Inst Med Res, Goroka, Papua N Guinea

[8] Univ London Imperial Coll Sci Technol & Med, London, England

来源：

PLOS MEDICINE | 2011年 / 8卷 / 01期

基金：

比尔及梅琳达.盖茨基金会;

关键词：

RED-BLOOD-CELLS; SACCHAROMYCES-CEREVISIAE GENOME; PARASITE PLASMODIUM-FALCIPARUM; ARTEMISININ RESISTANCE; DRUG DEVELOPMENT; MOSQUITO STAGES; AOTUS-MONKEYS; LIVER STAGE; STEM-CELLS; VIVAX;

D O I：

10.1371/journal.pmed.1000399

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Today's malaria control efforts are limited by our incomplete understanding of the biology of Plasmodium and of the complex relationships between human populations and the multiple species of mosquito and parasite. Research priorities include the development of in vitro culture systems for the complete life cycle of P. falciparum and P. vivax and the development of an appropriate liver culture system to study hepatic stages. In addition, genetic technologies for the manipulation of Plasmodium need to be improved, the entire parasite metabolome needs to be characterized to identify new druggable targets, and improved information systems for monitoring the changes in epidemiology, pathology, and host-parasite-vector interactions as a result of intensified control need to be established to bridge the gap between bench, preclinical, clinical, and population-based sciences.

引用

页数：6

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