RNA interference against viruses: strike and counterstrike

被引：217

作者：

Haasnoot, Joost ^{[1
]}

Westerhout, Ellen M. ^{[1
]}

Berkhout, Ben ^{[1
]}

机构：

[1] Univ Amsterdam, Acad Med Ctr, Ctr Infect & Immun Amsterdam CINIMA, Lab Expt Virol,Dept Med Microbiol, NL-1105 AZ Amsterdam, Netherlands

来源：

NATURE BIOTECHNOLOGY | 2007年 / 25卷 / 12期

关键词：

D O I：

10.1038/nbt1369

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

RNA interference (RNAi) is a conserved sequence-specific, gene-silencing mechanism that is induced by double-stranded RNA. RNAi holds great promise as a novel nucleic acid-based therapeutic against a wide variety of diseases, including cancer, infectious diseases and genetic disorders. Antiviral RNAi strategies have received much attention and several compounds are currently being tested in clinical trials. Although induced RNAi is able to trigger profound and specific inhibition of virus replication, it is becoming clear that RNAi therapeutics are not as straightforward as we had initially hoped. Difficulties concerning toxicity and delivery to the right cells that earlier hampered the development of antisense-based therapeutics may also apply to RNAi. In addition, there are indications that viruses have evolved ways to escape from RNAi. Proper consideration of all of these issues will be necessary in the design of RNAi-based therapeutics for successful clinical intervention of human pathogenic viruses.

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页码：1435 / 1443

页数：9

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