Identification of a series of 1,2,3,4-tetrahydroisoquinolinyl-benzamides with potential anticonvulsant activity

被引：9

作者：

Chan, WN ^{[1
]}

Hadley, MS ^{[1
]}

Harling, JD ^{[1
]}

Herdon, HJ ^{[1
]}

Jerman, JC ^{[1
]}

Orlek, BS ^{[1
]}

Stean, TO ^{[1
]}

Thompson, M ^{[1
]}

Upton, N ^{[1
]}

Ward, RW ^{[1
]}

机构：

[1] SmithKline Beecham Pharmaceut, Harlow CM19 5AW, Essex, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 20期

关键词：

anticonvulsant activity; molecular modelling; heterocyclic compounds; SB-204269 binding site;

D O I：

10.1016/S0960-894X(98)00523-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of N-(tetrahydroisoquinolinyl)-2-methoxybenzamides was identified by high-throughput screening at the novel SE-204269 binding site. SAR studies have provided compounds 4 and 14 with high affinity and good anticonvulsant activity in animal models. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：2903 / 2906

页数：4

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