Synthesis of deoxyvariolin B

被引：50

作者：

Alvarez, M ^{[1
]}

Fernández, D

Joule, JA

机构：

[1] Univ Barcelona, Fac Farm, Lab Quim Organ, E-08028 Barcelona, Spain

[2] Univ Manchester, Dept Chem, Manchester M13 9PL, Lancs, England

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 02期

关键词：

D O I：

10.1016/S0040-4039(00)01916-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A synthesis of deoxyvariolin B (5) is described. The tricyclic pyridopyrrolopyrimidone (11) was prepared from 7-azaindole via lithiation at C-2, introduction of an aminoethyl side-chain, then closure of the third ring. A heteroaryl palladium(0)-catalysed coupling reaction was used to introduce a pyrimidine substituent at C-5. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：315 / 317

页数：3

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