Effectiveness of high doses of Simvastatin as monotherapy in mixed hyperlipidemia

被引：19

作者：

Miller, M

Dolinar, C

Cromwell, W

Otvos, JD

机构：

[1] Univ Maryland, Med Ctr, Div Cardiol, Baltimore, MD 21201 USA

[2] N Carolina State Univ, Dept Biochem, Raleigh, NC 27695 USA

[3] N Carolina State Univ, Lipoprot & Metab Dis Inst, Raleigh, NC 27695 USA

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2001年 / 87卷 / 02期

关键词：

D O I：

10.1016/S0002-9149(00)01327-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Twenty subjects with mixed hyperlipidemia participated in a 3-arm crossover trial to evaluate the effectiveness of high-dose simvastatin as monotherapy. Significant reductions were observed in atherogenic lipids and lipoproteins, The highest dose of simvastatin also resulted in significant increases in high-density lipoprotein cholesterol (21%) with a comparable increase in large, protective high-density lipoprotein particles.

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页码：232 / +

页数：4

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