Synthetic studies of 18-membered anti-tumor macrolide, tedanolide. Computer-aided conformational design of a seco-acid derivative for efficient macrolactonization

被引:52
作者
Matsushima, T [1 ]
Horita, K [1 ]
Nakajima, N [1 ]
Yonemitsu, O [1 ]
机构
[1] HOKKAIDO UNIV,FAC PHARMACEUT SCI,SAPPORO,HOKKAIDO 060,JAPAN
关键词
D O I
10.1016/0040-4039(95)02182-5
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Computer-aided conformational analyses are successfully applied to the synthesis of a key intermediary 18-membered lactone of tedanolide (I). The design of a seco-acid derivative based on computation in order to achieve its efficient macro-lactonization is described.
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页码:385 / 388
页数:4
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