Synthetic studies of 18-membered anti-tumor macrolide, tedanolide. Computer-aided conformational design of a seco-acid derivative for efficient macrolactonization

被引：52

作者：

Matsushima, T ^{[1
]}

Horita, K ^{[1
]}

Nakajima, N ^{[1
]}

Yonemitsu, O ^{[1
]}

机构：

[1] HOKKAIDO UNIV,FAC PHARMACEUT SCI,SAPPORO,HOKKAIDO 060,JAPAN

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 03期

关键词：

D O I：

10.1016/0040-4039(95)02182-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Computer-aided conformational analyses are successfully applied to the synthesis of a key intermediary 18-membered lactone of tedanolide (I). The design of a seco-acid derivative based on computation in order to achieve its efficient macro-lactonization is described.

引用

页码：385 / 388

页数：4

共 12 条

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