CHIRAL SYNTHESIS OF POLYKETIDE-DERIVED NATURAL-PRODUCTS .31. STEREOSELECTIVE SYNTHESIS OF ERYTHRONOLIDE A BY EXTREMELY EFFICIENT LACTONIZATION BASED ON CONFORMATIONAL ADJUSTMENT AND HIGH ACTIVATION OF SECO-ACID

被引:80
作者
HIKOTA, M [1 ]
TONE, H [1 ]
HORITA, K [1 ]
YONEMITSU, O [1 ]
机构
[1] HOKKAIDO UNIV,FAC PHARMACEUT SCI,SAPPORO,HOKKAIDO 060,JAPAN
关键词
D O I
10.1016/S0040-4020(01)85585-X
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
C1-C5 sulfone (11) and C7-C15 aldehyde (20), synthesized stereoselectively from D- glucose, were coupled, and the C5 and C6 chiral centers were constructed taking advantage of the MPM (4-methoxybenzyl) type protecting group to give the seco-acid (7), which has 9,11-and 3,5- diols protected as the mesityl- and DMP (3,4-dimethoxyphenyl) acetals, respectively. When Yamaguchi's mixed anhydride of 7 was treated with a high concentration of DMAP at room temperature, a very rapid cyclization occurred and the 14-membered lactone (8) was isolated in almost quantitative yield. Deprotection of 8 readily gave 9-dihydroerythronolide A (2), which was converted to the title compound (1). © 1990.
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页码:4613 / 4628
页数:16
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