Molecular dissection of the vaccinia virus 17L core protein proteinase

被引：34

作者：

Byrd, CA

Bolken, TC

Hruby, DE

机构：

[1] Oregon State Univ, Dept Microbiol, Corvallis, OR 97331 USA

[2] Oregon State Univ, Mol & Cellular Biol Program, Corvallis, OR 97331 USA

[3] SIGA Technol Inc, Corvallis, OR 97333 USA

来源：

JOURNAL OF VIROLOGY | 2003年 / 77卷 / 20期

关键词：

D O I：

10.1128/JVI.77.20.11279-11283.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The vaccinia virus 17L gene product is predicted to be a cysteine proteinase and is demonstrated in this study to be responsible for cleavage of each of the three major core protein precursors (P4a, P4b, and P25K) in vivo. Mutagenesis of the putative catalytic triad of 17L or of the cleavage sites in the core protein precursors inhibits processing. A truncated protein lost the ability to cleave the core protein precursors.

引用

收藏

页码：11279 / 11283

页数：5

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