Role of poly(ADP-ribose) glycohydrolase (PARG) in shock, ischemia and reperfusion

被引：36

作者：

Cuzzocrea, S

Wang, ZQ

机构：

[1] Policlin Univ, Dept Clin & Expt Med & Pharmacol, I-98123 Messina, Italy

[2] Int Agcy Res Canc, F-69008 Lyon, France

来源：

PHARMACOLOGICAL RESEARCH | 2005年 / 52卷 / 01期

关键词：

PARG; PARP-1; tissue damage; inflammation; ischemia; shock;

D O I：

10.1016/j.phrs.2005.02.009

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Poly(ADP-ribosyl)ation is regulated by the synthesizing enzyme poly(ADP-ribose) polymerase-1 (PARP-1) and the degrading enzyme poly(ADP-ribose) glycohydrolase (PARG). Homeostasis of poly(ADP-ribosyl)ation has been proposed to be an important regulator for pathogenesis in multi-cellular organisms. Although the role of PARP-1 in tissue damage, inflammation and ischemia has been extensively studied, the function of PARG in various cellular processes is largely unknown. Recent studies using chemical inhibitors of PARG and genetically engineered Drosophila and mouse models that carry a disrupted PARG gene have started to shed new light on the biological function of PARG in vivo. These animal models and cells isolated from them will be useful for further validation of PARG as a potential pharmaceutical target to intervene the pathogenesis induced by acute tissue injury, ischemia and inflammation. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：100 / 108

页数：9

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