Quantitation of morphine and codeine in human urine using high-field asymmetric waveform ion mobility spectrometry (FAIMS) with mass spectrometric detection

被引：59

作者：

McCooeye, MA ^{[1
]}

Ells, B ^{[1
]}

Barnett, DA ^{[1
]}

Purves, RW ^{[1
]}

Guevremont, R ^{[1
]}

机构：

[1] Natl Res Council Canada, Inst Natl Measurement Stand, Ottawa, ON K1A 0R6, Canada

来源：

JOURNAL OF ANALYTICAL TOXICOLOGY | 2001年 / 25卷 / 02期

关键词：

D O I：

10.1093/jat/25.2.81

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Morphine and codeine have been identified and measured in a human urine matrix using high-field asymmetric waveform ion mobility spectrometry (FAIMS) in a tandem combination with electrospray ionization (ESI) and mass spectrometric (MS) detection. The addition of helium to the nitrogen carrier gas resulted in a substantial improvement in the sensitivity of the ESI-FAIMS-MS instrument for the determination of morphine and codeine. Limits of detection in human urine were 60 ng/mL for morphine and 20 ng/mL for codeine with no clean-up, derivatization, or chromatographic separation of the sample prior to analysis.

引用

页码：81 / 87

页数：7

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