Ambient air pollution and adverse birth outcomes: Methodologic issues in an emerging field

被引:190
作者
Ritz, Beate [1 ,2 ]
Wilhelm, Michelle [1 ,2 ]
机构
[1] Univ Calif Los Angeles, Sch Publ Hlth, Dept Epidemiol, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, Sch Publ Hlth, Ctr Occupat & Environm Hlth, Los Angeles, CA 90095 USA
关键词
D O I
10.1111/j.1742-7843.2007.00161.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Since the mid-1990s, the number of studies linking air pollutants to low birthweight, small for gestational age, preterm birth and cardiac birth defects has grown steadily. This MiniReview (in conjunction with the May 2007 International Conference on Foetal Programming and Development Toxicity) highlights key methodological issues surrounding this research area, based on our experiences in Southern California. All 'criteria' air pollutants have been linked to birth outcomes. Our own studies found most consistent associations for carbon monoxide and particles. Traffic exhaust toxins are possible causative agents, but air monitoring data relied on by almost all existing studies inadequately capture their intracommunity variability in concentrations. Exposure assessment might be improved by biomarkers and land use-based regression modelling or information on time-activity patterns. Foetal development provides unique opportunities to study exposures acting during narrow susceptibility windows. A time-series approach by design controls for confounders that do not vary temporally but can only address short-term acute effects. Studies employing spatial or medium-term (trimester-specific) temporal contrasts may be more susceptible to residual confounding, and studies adjusting only for risk factors recorded on birth certificates have been criticized. Findings from our recent study in Southern California indicate that air pollution effect estimates are not markedly influenced by risk factors not provided on birth certificates. Yet, studies collecting detailed risk factor information in other geographic regions may be needed to further evaluate the extent of residual confounding in record-based analyses. Investigating biological mechanisms (e.g. using ultrasound measurements and biomarkers for hypothesized pathways) is an important remaining issue.
引用
收藏
页码:182 / 190
页数:9
相关论文
共 64 条
  • [1] Andres R L, 2000, Semin Neonatol, V5, P231, DOI 10.1053/siny.2000.0025
  • [2] Detection of benzo[a]pyrene-DNA adducts in human placenta and umbilical cord blood
    Arnould, JP
    Verhoest, P
    Bach, V
    Libert, JP
    Belegaud, J
    [J]. HUMAN & EXPERIMENTAL TOXICOLOGY, 1997, 16 (12): : 716 - 721
  • [3] BARKER DJP, 1989, LANCET, V2, P577
  • [4] Biologic monitoring of exposure to environmental chemicals throughout the life stages: Requirements and issues for consideration for the National Children's Study
    Barr, DB
    Wang, RY
    Needham, LL
    [J]. ENVIRONMENTAL HEALTH PERSPECTIVES, 2005, 113 (08) : 1083 - 1091
  • [5] Ambient air pollution and low birth weight in Connecticut and Massachusetts
    Bell, Michelle L.
    Ebisu, Keita
    Belanger, Kathleen
    [J]. ENVIRONMENTAL HEALTH PERSPECTIVES, 2007, 115 (07) : 1118 - 1124
  • [6] Outdoor air pollution, low birth weight, and prematurity
    Bobak, M
    [J]. ENVIRONMENTAL HEALTH PERSPECTIVES, 2000, 108 (02) : 173 - 176
  • [7] Birth weight and exposure to kitchen wood smoke during pregnancy in rural Guatemala
    Boy, E
    Bruce, N
    Delgado, H
    [J]. ENVIRONMENTAL HEALTH PERSPECTIVES, 2002, 110 (01) : 109 - 114
  • [8] Air pollution and health
    Brunekreef, B
    Holgate, ST
    [J]. LANCET, 2002, 360 (9341) : 1233 - 1242
  • [9] Fetal growth in early pregnancy and risk of delivering low birth weight infant: prospective cohort study
    Bukowski, R.
    Smith, G. C. S.
    Malone, F. D.
    Ball, R. H.
    Nyberg, D. A.
    Comstock, C. H.
    Hankins, G. D. V.
    Berkowitz, R. L.
    Gross, S. J.
    Dugoff, L.
    Craigo, S. D.
    Timor-Tritsch, I. E.
    Carr, S. R.
    Wolfe, H. M.
    D'Alton, M. E.
    [J]. BMJ-BRITISH MEDICAL JOURNAL, 2007, 334 (7598): : 836 - 838
  • [10] Redox activity of airborne particulate matter at different sites in the Los Angeles Basin
    Cho, AK
    Sioutas, C
    Miguel, AH
    Kumagai, Y
    Schmitz, DA
    Singh, M
    Eiguren-Fernandez, A
    Froines, JR
    [J]. ENVIRONMENTAL RESEARCH, 2005, 99 (01) : 40 - 47