Novell stilbenes isolated from the root bark of Ekebergia benguelensis

被引：16

作者：

Chávez, D

Chai, HB

Chagwedera, TE

Gao, Q

Farnsworth, NR

Cordell, GA

Pezzuto, JM

Kinghorn, AD ^{[1
]}

机构：

[1] Univ Illinois, Coll Pharm, Program Collaborat Res Pharmaceut Sci, Chicago, IL 60612 USA

[2] Univ Illinois, Coll Pharm, Dept Med Chem & Pharmacognosy, Chicago, IL 60612 USA

[3] Univ Zimbabwe, Dept Pharm, Harare, Zimbabwe

[4] Bristol Myers Squibb Co, Pharmaceut Res Inst, Wallingford, CT 06492 USA

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 22期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4039(01)00560-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Four novel stilbenes (1-4) were isolated from the root bark of Ekebergia benguelensis. The structures were established by spectroscopic methods including 2D NMR analysis. The structure of I, a new stilbene-coumarin hybrid representing a novel skeleton, was confirmed by single X-ray analysis. Compounds 1-4 were evaluated against a panel of human cancer cell lines. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：3685 / 3688

页数：4

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