On the benefit of probiotics in the management of pouchitis in patients underwent ileal pouch anal anastomosis: A meta-analysis of controlled clinical trials

被引：93

作者：

Elahi, Behzad ^{[3
]}

Nikfar, Shekoufeh ^{[4
,5
]}

Derakhshani, Saeed ^{[6
]}

Vafaie, Mohammad ^{[6
]}

Abdollahi, Mohammad ^{[1
,2
]}

机构：

[1] Tehran Univ Med Sci, Fac Pharm, Tehran, Iran

[2] Tehran Univ Med Sci, Pharmaceut Sci Res Ctr, Tehran, Iran

[3] Univ Tehran Med Sci, Sch Med, Tehran, Iran

[4] Minist Hlth & Med Educ, Food & Drug Org, Drug Selecting Comm, Tehran, Iran

[5] Minist Hlth & Med Educ, Food & Drug Lab Res Ctr, Tehran, Iran

[6] Baharan Coloproctol Surg Clin, Tehran, Iran

来源：

DIGESTIVE DISEASES AND SCIENCES | 2008年 / 53卷 / 05期

关键词：

pouchitis; probiotics; ileal pouch anal anastomosis; meta-analysis;

D O I：

10.1007/s10620-007-0006-z

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The objective of this study was to evaluate and collect current evidence on the effect of probiotics in preventing pouchitis after restorative ileal pouch anal anastomosis (IPAA). The Pubmed, Medline, EMbase, CINAHL, Web of Science, and Scopus bibliographic, and Google Scholar databases were searched between 1966 and May 2007, and relevant controlled clinical trials were extracted, reviewed, and validated according to the study protocol. The outcome of interest was for pouchitis defined by a pouchitis disease activity index (PDAI) 7. Five randomized, placebo-controlled clinical trials were included in the meta-analysis. Pooling of the results from these trials yielded an odds ratio (OR) of 0.04 with a 95% CI of 0.01-0.14 (P < 0.0001) in the treatment group in comparison with the placebo group. In conclusion, the benefit of probiotics in the management of pouchitis after IPAA operation was confirmed by the meta-analysis.

引用

页码：1278 / 1284

页数：7

共 32 条

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Meta-analysis of observational studies of ileorectal versus ileal pouch-anal anastomosis for familial adenomatous polyposis [J].