Low muscle mass and low muscle strength associate with nonalcoholic fatty liver disease

被引：81

作者：

Gan, Da ^{[1
,2
,3
]}

Wang, Lu ^{[1
,2
,3
]}

Jia, Menghan ^{[1
,2
,3
]}

Ru, Yuan ^{[1
,2
,3
]}

Ma, Yiyun ^{[4
]}

Zheng, Weifang ^{[5
]}

Zhao, Xueyin ^{[1
,2
,3
]}

Yang, Fei ^{[1
,2
,3
]}

Wang, Tianru ^{[6
]}

Mu, Yun ^{[7
]}

Zhu, Shankuan ^{[1
,2
,3
]}

机构：

[1] Zhejiang Univ, Sch Med, Sch Publ Hlth, Chron Dis Res Inst, Hangzhou, Zhejiang, Peoples R China

[2] Zhejiang Univ, Sch Med, Womens Hosp, 866 Yu Hang Tang Rd, Hangzhou 310058, Zhejiang, Peoples R China

[3] Zhejiang Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Hangzhou, Zhejiang, Peoples R China

[4] Tsinghua Univ, Sch Humanities, English Dept, Beijing, Peoples R China

[5] Lanxi Red Cross Hosp, Lanxi, Zhejiang, Peoples R China

[6] Univ Toronto, Fac Arts & Sci, Dept Nutr Sci, Toronto, ON, Canada

[7] Zhejiang Univ, Affiliated Hosp 1, Echocardiog & Vasc Ultrasound Ctr, Sch Med, Hangzhou, Zhejiang, Peoples R China

来源：

CLINICAL NUTRITION | 2020年 / 39卷 / 04期

关键词：

Muscle mass; Muscle strength; Sarcopenia; Sarcopenic obesity; Nonalcoholic fatty liver disease; SARCOPENIC-OBESITY; RISK-FACTORS; INSULIN-RESISTANCE; METABOLIC SYNDROME; PHYSICAL-ACTIVITY; PREVALENCE; DEFINITION; MORTALITY; HEALTH; ADULTS;

D O I：

10.1016/j.clnu.2019.04.023

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 [营养与食品卫生学];

摘要：

Background: It is unclear whether low muscle mass and low muscle strength are independently or jointly associated with nonalcoholic fatty liver disease (NAFLD). Hence, the aim of the present study was to investigate the associations of NAFLD with low muscle mass, low muscle strength, sarcopenia, and sarcopenic obesity. Methods: A total of 5132 participants aged 18-80 years were recruited in this cross-sectional study. NAFLD was diagnosed using ultrasound. Muscle mass was evaluated using skeletal muscle mass index and muscle strength was evaluated using weight-adjusted hand grip strength. Sarcopenia was defined as the presence of both low muscle mass and low muscle strength. Sarcopenic obesity was defined as the presence of both sarcopenia and obesity. Multivariate logistic regression models were used to explore the associations of NAFLD with low muscle mass, low muscle strength, sarcopenia, and sarcopenic obesity. Results: Low muscle mass and low muscle strength were positively and independently associated with NAFLD (mass: odds ratio [OR], 2.57; 95% confidence interval [CI], 2.03-3.25; strength: OR, 1.47; 95% CI, 1.21-1.80). Compared with low muscle mass or low muscle strength alone, sarcopenia was associated with a higher risk of NAFLD (OR, 3.91; 95% CI, 2.90-5.28). Whether obesity was defined by body mass index (BMI) or waist circumference (WC), sarcopenic obesity was associated with a higher risk of NAFLD (BMI: OR, 10.42; 95% CI, 7.14-15.22; WC: OR, 11.64; 95% CI, 8.22-16.48) than sarcopenia or obesity alone. Conclusions: Low muscle mass and low muscle strength were positively and independently associated with NAFLD. When both were presented in the sarcopenic state, the risk of NAFLD was higher, and a concurrence of sarcopenia and obesity showed the highest risk of NAFLD. (C) 2019 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

引用

页码：1124 / 1130

页数：7

共 46 条

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