Metalloproteinases: Mediators of pathology and regeneration in the CNS

被引：457

作者：

Yong, VW

机构：

[1] Univ Calgary, Hotchkiss Brain Inst, Calgary, AB T2N 4N1, Canada

[2] Univ Calgary, Dept Clin Neurosci, Calgary, AB T2N 4N1, Canada

[3] Univ Calgary, Dept Oncol, Calgary, AB T2N 4N1, Canada

来源：

NATURE REVIEWS NEUROSCIENCE | 2005年 / 6卷 / 12期

关键词：

D O I：

10.1038/nrn1807

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The matrix metalloproteinases and related A disintegrin and metalloproteinase enzymes are implicated in various diseases of the nervous system. However, metalloproteinases are increasingly being recognized as having beneficial roles during nervous system development and following injury. This review discusses general principles that govern the expression of metalloproteinases in the nervous system and their detrimental outcomes. It then focuses on the roles of metalloproteinases and their mechanisms in regulating neurogenesis, myelin formation and axonal growth. It is clear that metalloproteinases are important determinants in enabling recovery from injury to the nervous system.

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页码：931 / 944

页数：14

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