Updates on acetaminophen toxicity

被引：39

作者：

Rowden, AK

Norvell, J

Eldridge, DL

Kirk, MA

机构：

[1] Univ Virginia, Dept Emergency Med, Div Med Toxicol, Charlottesville, VA 22908 USA

[2] Univ Missouri Kansas City, Truman Med Ctr, Kansas City, MO USA

[3] E Carolina Univ, Brody Sch Med, Dept Pediat, Greenville, SC USA

来源：

MEDICAL CLINICS OF NORTH AMERICA | 2005年 / 89卷 / 06期

关键词：

D O I：

10.1016/j.mcna.2005.06.009

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Acetaminophen (acetyl-para-amino-phenol or APAP), an antipyretic and analgesic, is a common component in hundreds of over-the-counter and prescription medications. The wide usage of this drug results in many potentially toxic exposures. It is therefore critical for the clinician to be comfortable with the diagnosis and treatment of APAP toxicity. Prompt recognition of APAP overdose and institution of appropriate therapy are essential to preventing morbidity and mortality.

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收藏

页码：1145 / +

页数：16

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共 90 条

[1]

Early indicators of prognosis in fulminant hepatic failure: An assessment of the King's criteria [J].

Anand, AC ;

Nightingale, P ;

Neuberger, JM .

JOURNAL OF HEPATOLOGY, 1997, 26 (01) :62-68

[2]

Fatal anaphylactoid reaction to N-acetylcysteine: caution in patients with asthma [J].

Appelboam, AV ;

Dargan, PI ;

Knighton, J .

EMERGENCY MEDICINE JOURNAL, 2002, 19 (06) :594-595

[3]

VALUE OF RAPID SCREENING FOR ACETAMINOPHEN IN ALL PATIENTS WITH INTENTIONAL DRUG OVERDOSE [J].

ASHBOURNE, JF ;

OLSON, KR ;

KHAYAMBASHI, H .

ANNALS OF EMERGENCY MEDICINE, 1989, 18 (10) :1035-1038

[4]

Fulminant hepatic failure secondary to acetaminophen poisoning: A systematic review and meta-analysis of prognostic criteria determining the need for liver transplantation [J].

Bailey, B ;

Amre, DK ;

Gaudreault, P .

CRITICAL CARE MEDICINE, 2003, 31 (01) :299-305

[5]

Management of anaphylactoid reactions to intravenous N-acetylcysteine [J].

Bailey, B ;

McGuigan, MA .

ANNALS OF EMERGENCY MEDICINE, 1998, 31 (06) :710-715

[6]

Acetaminophen-induced oxidant stress and cell injury in cultured mouse hepatocytes:: Protection by N-acetyl cysteine [J].

Bajt, ML ;

Knight, TR ;

Lemasters, JJ ;

Jaeschke, H .

TOXICOLOGICAL SCIENCES, 2004, 80 (02) :343-349

[7]

Blood lactate as an early predictor of outcome in paracetamol-induced acute liver failure: a cohort study [J].

Bernal, W ;

Donaldson, N ;

Wyncoll, D ;

Wendon, J .

LANCET, 2002, 359 (9306) :558-563

[8]

Late increase in acetaminophen concentration after overdose of Tylenol Extended Relief [J].

Bizovi, KE ;

Aks, SE ;

Paloucek, F ;

Gross, R ;

Keys, N ;

Rivas, J .

ANNALS OF EMERGENCY MEDICINE, 1996, 28 (05) :549-551

[9]

Phenytoin as a possible cause of acetaminophen hepatotoxicity: Case report and review of the literature [J].

Brackett, CC ;

Bloch, JD .

PHARMACOTHERAPY, 2000, 20 (02) :229-233

[10]

LONG-TERM ANTICONVULSANT THERAPY WORSENS OUTCOME IN PARACETAMOL-INDUCED FULMINANT HEPATIC-FAILURE [J].

BRAY, GP ;

HARRISON, PM ;

OGRADY, JG ;

TREDGER, JM ;

WILLIAMS, R .

HUMAN & EXPERIMENTAL TOXICOLOGY, 1992, 11 (04) :265-270

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