Enzymatic synthesis of tea theaflavin derivatives and their anti-inflammatory and cytotoxic activities

被引：128

作者：

Sang, SM

Lambert, JD

Tian, SY

Hong, JL

Hou, Z

Ryu, JH

Stark, RE

Rosen, RT

Huang, MT

Yang, CS

Ho, CT

机构：

[1] Rutgers State Univ, Ernest Mario Sch Pharm, Dept Biol Chem, Piscataway, NJ 08854 USA

[2] Rutgers State Univ, Dept Food Sci, New Brunswick, NJ 08901 USA

[3] Rutgers State Univ, Ctr Adv Food Technol, New Brunswick, NJ 08901 USA

[4] CUNY Coll Staten Isl, Dept Chem, Staten Isl, NY 10314 USA

[5] CUNY Coll Staten Isl, Inst Macromol Assemblies, Staten Isl, NY 10314 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2004年 / 12卷 / 02期

关键词：

black tea; theaflavins; benzotropolone; enzymatic synthesis; peroxidase; anti-inflammatory activities; cytotoxic activities;

D O I：

10.1016/j.bmc.2003.10.024

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Derivatives based on a benzotropolone skeleton (9-26) have been prepared by the enzymatic coupling (horseradish peroxidase/H2O2) of selected pairs of compounds (1-8), one with a vic-trihydroxyphenyl moiety, and the other with an ortho-dihydroxyphenyl structure. Some of these compounds have been found to inhibit TPA-induced mice ear edema, nitric oxide (NO) synthesis, and arachidonic acid release by LPS-stimulated RAW 264.7 cells. Their cytotoxic activites against KYSE 150 and 510 human esophageal squamous cell carcinoma and HT 29 human colon cancer cells were also evaluated. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：459 / 467

页数：9

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[11] GRADIENT-ENHANCED PROTON-DETECTED HETERONUCLEAR MULTIPLE-QUANTUM COHERENCE SPECTROSCOPY [J].