Rhodium-catalyzed α-fluoroalkylation reaction of ketones using silyl enol ethers

被引：32

作者：

Sato, Kazuyuki ^{[1
]}

Higashinagata, Makoto ^{[1
]}

Yuki, Takashi ^{[1
]}

Tarui, Atsushi ^{[1
]}

Omote, Masaaki ^{[1
]}

Kumadaki, Itsumaro ^{[1
]}

Ando, Akira ^{[1
]}

机构：

[1] Setsunan Univ, Fac Pharmaceut Sci, Osaka 5730101, Japan

来源：

JOURNAL OF FLUORINE CHEMISTRY | 2008年 / 129卷 / 01期

关键词：

fluorine; rhodium; silyl enol ethers; alpha-fluoroalkylation;

D O I：

10.1016/j.jfluchem.2007.08.013

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The treatment of silyl enol ethers with fluoroalkyl halides (R-f-X) in the presence of RhCl(PPh3)(3) gave alpha-fluoroalkylated ketones. It seems that a rhodium complex derived from the silyl enol ether and RhCl(PPh3)(3) played an important role for the oxidative addition of fluoroalkyl halides and the reductive elimination of the product. (C) 2007 Elsevier B.V. All rights reserved.

引用

页码：51 / 55

页数：5

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