Regional brain metabolic activation during craving elicited by recall of previous drug experiences

被引:267
作者
Wang, GJ [1 ]
Volkow, ND
Fowler, JS
Cervany, P
Hitzemann, RJ
Pappas, NR
Wong, CT
Felder, C
机构
[1] Brookhaven Natl Lab, Dept Med, Upton, NY 11973 USA
[2] Brookhaven Natl Lab, Dept Chem, Upton, NY 11973 USA
[3] SUNY Stony Brook, Dept Radiol, Stony Brook, NY 11794 USA
[4] SUNY Stony Brook, Dept Psychiat, Stony Brook, NY 11794 USA
[5] VA Med Ctr, Psychiat Serv, Northport, NY USA
关键词
cocaine abuser; cocaine cue; FDG; positron emission tomography;
D O I
10.1016/S0024-3205(98)00619-5
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Cocaine cues elicit craving and physiological responses. The cerebral circuits involved in these are poorly understood. The purpose of this study was to assess the relation between regional brain activation and cocaine cue elicited responses. Thirteen right-handed cocaine abusers were scanned with positron emission tomography (PET) and [F-18] fluorodeoxyglucose (FDG) twice; during an interactive interview about neutral themes and during an interactive interview about cocaine themes designed to elicit cocaine craving. In parallel the behavioral (rated from 0: felt nothing to 10: felt extreme) and cardiovascular responses were recorded. During the cocaine theme interview subjects reported higher self reports for cocaine craving (+2.5+/-3.3, p less than or equal to 0.02) and had higher heart rates (+4.7+/-7.2%, p less than or equal to 0.001), systolic (+4+/-4%, p less than or equal to 0.0001), and diastolic blood pressures (+2.6+/-3.8%, p less than or equal to 0.003) than during the neutral interview. Absolute and relative metabolic values in the orbitofrontal (+16.4+/-17.1%, p 0.005; +11.3+/-14.3%, p less than or equal to 0.008) and left insular cortex (+21.6+/-19.6%, p less than or equal to 0.002; +16.7+/-19.7%, p less than or equal to 0.01) and relative values in cerebellum (+17.9+/-14.8%, p less than or equal to 0.0008) were higher during the cocaine theme than during the neutral theme interview. Relative metabolic values in the right insular region (p less than or equal to 0.0008) were significantly correlated with self reports of cocaine craving. Activation of the temporal insula, a brain region involved with autonomic control, and of the orbitofrontal cortex, a brain region involved with expectancy and reinforcing salience of stimuli, during the cocaine theme support their involvement with craving in cocaine addicted subjects.
引用
收藏
页码:775 / 784
页数:10
相关论文
共 45 条
[21]  
Gawin F H, 1996, NIDA Res Monogr, V163, P224
[22]   COCAINE AND OTHER STIMULANTS - ACTIONS, ABUSE, AND TREATMENT [J].
GAWIN, FH ;
ELLINWOOD, EH .
NEW ENGLAND JOURNAL OF MEDICINE, 1988, 318 (18) :1173-1182
[23]   Understanding emotional prosody activates right hemisphere regions [J].
George, MS ;
Parekh, PI ;
Rosinsky, N ;
Ketter, TA ;
Kimbrell, TA ;
Heilman, KM ;
Herscovitch, P ;
Post, RM .
ARCHIVES OF NEUROLOGY, 1996, 53 (07) :665-670
[24]   Mental navigation along memorized routes activates the hippocampus, precuneus, and insula [J].
Ghaem, O ;
Mellet, E ;
Crivello, F ;
Tzourio, N ;
Mazoyer, B ;
Berthoz, A ;
Denis, M .
NEUROREPORT, 1997, 8 (03) :739-744
[25]   Activation of memory circuits during cue-elicited cocaine craving [J].
Grant, S ;
London, ED ;
Newlin, DB ;
Villemagne, VL ;
Liu, X ;
Contoreggi, C ;
Phillips, RL ;
Kimes, AS ;
Margolin, A .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (21) :12040-12045
[26]   BRAIN MECHANISMS IN HUMAN CLASSICAL-CONDITIONING - A PET BLOOD-FLOW STUDY [J].
HUGDAHL, K ;
BERARDI, A ;
THOMPSON, WL ;
KOSSLYN, SM ;
MACY, R ;
BAKER, DP ;
ALPERT, NM ;
LEDOUX, JE .
NEUROREPORT, 1995, 6 (13) :1723-1728
[27]  
JENKINS IH, 1994, J NEUROSCI, V14, P3775
[28]   Cue reactivity in cocaine-dependent subjects: Effects of cue type and cue modality [J].
Johnson, BA ;
Chen, YR ;
Schmitz, J ;
Bordnick, P ;
Shafer, A .
ADDICTIVE BEHAVIORS, 1998, 23 (01) :7-15
[29]   EXPERIMENTAL MANIPULATION OF COCAINE CRAVING BY VIDEOTAPED ENVIRONMENTAL CUES [J].
KILGUS, MD ;
PUMARIEGA, AJ .
SOUTHERN MEDICAL JOURNAL, 1994, 87 (11) :1138-1140
[30]   Neural effects of visualizing and perceiving aversive stimuli: A PET investigation [J].
Kosslyn, SM ;
Shin, LM ;
Thompson, WL ;
McNally, RJ ;
Rauch, SL ;
Pitman, RK ;
Alpert, NM .
NEUROREPORT, 1996, 7 (10) :1569-1576