Novel nuclear signaling pathway mediates activation of fibroblast growth factor-2 gene by type 1 and type 2 angiotensin II receptors

被引：85

作者：

Peng, H

Moffett, J

Myers, J

Fang, XH

Stachowiak, EK

Maher, P

Kratz, E

Hines, J

Fluharty, SJ

Mizukoshi, E

Bloom, DC

Stachowiak, MK ^{[1
]}

机构：

[1] SUNY Buffalo, Mol & Struct Neurobiol & Gene Therapy Program, Buffalo, NY 14214 USA

[2] Arizona State Univ, Tempe, AZ 85287 USA

[3] Scripps Res Inst, La Jolla, CA 92037 USA

[4] Univ Penn, Sch Med, Philadelphia, PA 19104 USA

[5] Univ Penn, Sch Vet Med, Philadelphia, PA 19104 USA

来源：

MOLECULAR BIOLOGY OF THE CELL | 2001年 / 12卷 / 02期

关键词：

D O I：

10.1091/mbc.12.2.449

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In bovine adrenal medullary cells synergistically acting type 1 and type 2 angiotensin II (AII) receptors activate the fibroblast growth factor-2 (FGF-2) gene through a unique AII-responsive promoter element. Both the type I and type 2 All receptors and the downstream cyclic adenosine 1',3'-monophosphate- and protein kinase C-dependent signaling pathways activate the FGF-2 promoter through a novel signal-transducing mechanism. This mechanism, which we have named integrative nuclear FGF receptor-1 signaling, involves the nuclear translocation of FGF receptor-1 and its subsequent transactivation of the AII-responsive element in the FGF-2 promoter.

引用

收藏

页码：449 / 462

页数：14

相关论文

共 54 条

[21] ANGIOTENSIN-II RECEPTOR SUBTYPES AND PHOSPHOINOSITIDE HYDROLYSIS IN RAT ADRENAL-MEDULLA [J].

ISRAEL, A ;

STROMBERG, C ;

TSUTSUMI, K ;

GARRIDO, MD ;

TORRES, M ;

SAAVEDRA, JM .

BRAIN RESEARCH BULLETIN, 1995, 38 (05) :441-446

[22] MULTIPLE AUTOCRINE GROWTH-FACTORS MODULATE VASCULAR SMOOTH-MUSCLE CELL-GROWTH RESPONSE TO ANGIOTENSIN-II [J].

ITOH, H ;

MUKOYAMA, M ;

PRATT, RE ;

GIBBONS, GH ;

DZAU, VJ .

JOURNAL OF CLINICAL INVESTIGATION, 1993, 91 (05) :2268-2274

[23]

Jagadeesh Gowraganahalli, 1998, Indian Journal of Experimental Biology, V36, P1171

[24] Nuclear accumulation of FGF-2 is associated with proliferation of human astrocytes and glioma cells [J].

Joy, A ;

Moffett, J ;

Neary, K ;

Mordechai, E ;

Stachowiak, EK ;

Coons, S ;

RankinShapiro, J ;

Florkiewicz, RZ ;

Stachowiak, MK .

ONCOGENE, 1997, 14 (02) :171-183

[25] Sustained phospholipase D activation in response to angiotensin II but not carbachol in bovine adrenal glomerulosa cells [J].

Jung, EM ;

Betancourt-Calle, S ;

Mann-Blakeney, R ;

Foushee, T ;

Isales, CM ;

Bollag, WB .

BIOCHEMICAL JOURNAL, 1998, 330 :445-451

[26] Cruciform-extruding regulatory element controls cell-specific activity of the tyrosine hydroxylase gene promoter [J].

Kim, EL ;

Peng, H ;

Esparza, FM ;

Maltchenko, SZ ;

Stachowiak, MK .

NUCLEIC ACIDS RESEARCH, 1998, 26 (07) :1793-1800

[27] Angiotensin II stimulates secretion of endogenous ouabain from bovine adrenocortical cells via angiotensin type 2 receptors [J].

Laredo, J ;

Shah, JR ;

Lu, ZR ;

Hamilton, BP ;

Hamlyn, JM .

HYPERTENSION, 1997, 29 (01) :401-407

[28] CELL-TRANSFORMATION BY FIBROBLAST GROWTH-FACTORS CAN BE SUPPRESSED BY TRUNCATED FIBROBLAST GROWTH-FACTOR RECEPTORS [J].

LI, Y ;

BASILICO, C ;

MANSUKHANI, A .

MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (11) :7660-7669

[29] Nuclear translocation of fibroblast growth factor (FGF) receptors in response to FGF-2 [J].

Maher, PA .

JOURNAL OF CELL BIOLOGY, 1996, 134 (02) :529-536

[30] TGF-β signal transduction [J].

Massagué, J .

ANNUAL REVIEW OF BIOCHEMISTRY, 1998, 67 :753-791

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