The Yin and Yang of centromeric cohesion of sister chromatids: mitotic kinases meet protein phosphatase 2A

被引：10

作者：

Dai, Wei ^{[1
]}

Wang, Xiaoxing ^{[1
]}

机构：

[1] New York Med Coll, Dept Med, Div Mol Carcinogenesis, Valhalla, NY 10595 USA

来源：

CELL DIVISION | 2006年 / 1卷 / 1期

关键词：

Sister Chromatid; Fission Yeast; Centromeric Protein; Sister Chromatid Cohesion; PP2A Activity;

D O I：

10.1186/1747-1028-1-9

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Accurate chromosome segregation during meiosis and mitosis is essential for the maintenance of genomic stability. Defects in the regulation of chromosome segregation during division predispose cells to undergo mitotic catastrophe or neoplastic transformation. Cohesin, a molecular glue holding sister chromatids together, is removed from chromosomes in a stepwise fashion during mitosis and meiosis. Cohesin at centromeres but not on chromosome arm remains intact until anaphase onset during early mitosis and the initiation of anaphase II during meiosis. Several recent studies indicate that the activity of protein phosphatase 2A is essential for maintaining the integrity of centromeric cohesin. Shugoshin, a guardian for sister chromatid segregation, may cooperate with and/or mediate PP2A function by suppressing the phosphorylation status of centromeric proteins including cohesin.

引用

页数：4

共 24 条

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