TLR2 and RIP2 Pathways Mediate Autophagy of Listeria monocytogenes via Extracellular Signal-regulated Kinase (ERK) Activation

被引：113

作者：

Anand, Paras K. ^{[1
]}

Tait, Stephen W. G. ^{[1
]}

Lamkanfi, Mohamed ^{[2
,3
]}

Amer, Amal O. ^{[4
,5
]}

Nunez, Gabriel ^{[6
]}

Pages, Gilles ^{[7
]}

Pouyssegur, Jacques ^{[7
]}

McGargill, Maureen A. ^{[1
]}

Green, Douglas R. ^{[1
]}

Kanneganti, Thirumala-Devi ^{[1
]}

机构：

[1] St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA

[2] Univ Ghent, Dept Biochem, B-9000 Ghent, Belgium

[3] Flanders Inst Biotechnol, Dept Med Prot Res, B-9000 Ghent, Belgium

[4] Ohio State Univ, Dept Internal Med, Div Pulm Allergy Crit Care & Sleep Med, Columbus, OH 43210 USA

[5] Ohio State Univ, Ctr Microbial Interface Biol, Columbus, OH 43210 USA

[6] Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA

[7] CNRS UMR 6543 Ctr A, Inst Dev Biol & Canc Res, F-06189 Nice, France

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2011年 / 286卷 / 50期

关键词：

GENOME-WIDE ASSOCIATION; INNATE IMMUNITY; INTRACELLULAR PATHOGENS; CRYOPYRIN INFLAMMASOME; ADAPTIVE IMMUNITY; EPITHELIAL-CELLS; CROHN-DISEASE; HOST-DEFENSE; EARLY PHASE; INFECTION;

D O I：

10.1074/jbc.M111.310599

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Background: Listeria monocytogenes is an intracellular pathogen that invades the host cytoplasm. Results: Cells deficient in TLR2 and NOD2 show defective autophagy of Listeria monocytogenes. Conclusion: Autophagy of Listeria is dependent on ERK pathway that is perturbed in TLR2- and NOD2-deficient cells. Significance: Our study establishes the role of innate immune receptors in autophagy of intracellular pathogens.

引用

页码：42981 / 42991

页数：11

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