Human barrier recovery after acute acetone perturbation: an irritant dermatitis model

被引：17

作者：

Zhai, H ^{[1
]}

Leow, YH ^{[1
]}

Maibach, HI ^{[1
]}

机构：

[1] Univ Calif San Francisco, Sch Med, Dept Dermatol, San Francisco, CA 94143 USA

来源：

CLINICAL AND EXPERIMENTAL DERMATOLOGY | 1998年 / 23卷 / 01期

关键词：

D O I：

10.1046/j.1365-2230.1998.00310.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The efficacy of a topical agent in barrier recovery was evaluated after acetone-induced acute water loss barrier disruption in vivo in humans. The upper back of several volunteers was rubbed with acetone-soaked cotton balls until elevated rates of transepidermal water loss (TEWL) occurred (> 20 g/m(2)h, or greater). The topical agent was then applied to the acetone-treated skin sites once daily for 5 days. Resolution evaluation used TEWL measurements and the data were expressed as the percentage recovery in water barrier function. In comparison with placebo control the topical agent significantly enhanced barrier recovery, especially within the first 72 h (P < 0.05). This model offers a simple method of examining chemicals accelerating (or inhibiting) repair of this form of acute skin damage in man.

引用

页码：11 / 13

页数：3

共 17 条

[11]

Pickart L., 1987, BIOL COPPER COMPLEXE, P273

[12] GUIDELINES FOR TRANSEPIDERMAL WATER-LOSS (TEWL) MEASUREMENT - A REPORT FROM THE STANDARDIZATION-GROUP-OF-THE EUROPEAN-SOCIETY-OF-CONTACT-DERMATITIS [J].

PINNAGODA, J ;

TUPKER, RA ;

AGNER, T ;

SERUP, J .

CONTACT DERMATITIS, 1990, 22 (03) :164-178

[13]

PINSKI J B, 1987, P196

[14]

ROVEE DT, 1972, EPIDERMAL WOUND HEAL, P159

[15]

Wahlberg JE, 1996, CURR PROBL DERMATOL, V25, P57

[16]

YANG L, 1995, BRIT J DERMATOL, V133, P679

[17]

Zhai HB, 1996, CURR PROBL DERMATOL, V25, P193

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