A default mode of brain function: A brief history of an evolving idea

被引:1545
作者
Ralchle, Marcus E.
Snyder, Abraham Z.
机构
[1] Washington Univ, Sch Med, Dept Radiol, St Louis, MO 63110 USA
[2] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA
[3] Washington Univ, Sch Med, Dept Neurobiol, St Louis, MO 63110 USA
关键词
D O I
10.1016/j.neuroimage.2007.02.041
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The concept of a default mode of brain function arose out of a focused need to explain the appearance of activity decreases in functional neuroimaging data when the control state was passive visual fixation or eyes closed resting. The problem was particularly compelling because these activity decreases were remarkably consistent across a wide variety of task conditions. Using PET, we determined that these activity decreases did not arise from activations in the resting state. Hence, their presence implied the existence of a default mode. While the unique constellation of brain areas provoking this analysis has come to be known as the default system, all areas of the brain have a high level of organized default functional activity. Most critically, this work has called attention to the importance of intrinsic functional activity in assessing brain behavior relationships. (c) 2007 Elsevier Inc. All rights reserved.
引用
收藏
页码:1083 / 1090
页数:8
相关论文
共 84 条
[51]   Time-related increase of oxygen utilization in continuously activated human visual cortex [J].
Mintun, MA ;
Vlassenko, AG ;
Shulman, GL ;
Snyder, AZ .
NEUROIMAGE, 2002, 16 (02) :531-537
[52]   Does the brain have a baseline?: Why we should be resisting a rest [J].
Morcom, Alexa M. ;
Fletcher, Paul C. .
NEUROIMAGE, 2007, 37 (04) :1073-1082
[53]   BRAIN MAGNETIC-RESONANCE-IMAGING WITH CONTRAST DEPENDENT ON BLOOD OXYGENATION [J].
OGAWA, S ;
LEE, TM ;
KAY, AR ;
TANK, DW .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (24) :9868-9872
[54]   INTRINSIC SIGNAL CHANGES ACCOMPANYING SENSORY STIMULATION - FUNCTIONAL BRAIN MAPPING WITH MAGNETIC-RESONANCE-IMAGING [J].
OGAWA, S ;
TANK, DW ;
MENON, R ;
ELLERMANN, JM ;
KIM, SG ;
MERKLE, H ;
UGURBIL, K .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (13) :5951-5955
[55]  
Olshausen B. A., 2003, The Visual Neurosciences, V2, P1603
[56]   How close are we to understanding V1? [J].
Olshausen, BA ;
Field, DJ .
NEURAL COMPUTATION, 2005, 17 (08) :1665-1699
[57]   Food for thought: Challenging the dogmas [J].
Pellerin, L ;
Magistretti, PJ .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2003, 23 (11) :1282-1286
[58]   Catecholaminergic activation in acute myocardial infarction:: Time course and relation to left ventricular performance [J].
Petersen, CL ;
Nielsen, JR ;
Petersen, BL ;
Kjær, A .
CARDIOLOGY, 2003, 100 (01) :23-28
[59]   The effects of practice on the functional anatomy of task performance [J].
Petersen, SE ;
van Mier, H ;
Fiez, JA ;
Raichle, ME .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (03) :853-860
[60]   5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression [J].
Pezawas, L ;
Meyer-Lindenberg, A ;
Drabant, EM ;
Verchinski, BA ;
Munoz, KE ;
Kolachana, BS ;
Egan, MF ;
Mattay, VS ;
Hariri, AR ;
Weinberger, DR .
NATURE NEUROSCIENCE, 2005, 8 (06) :828-834