Simultaneous high-performance liquid chromatographic determination of urinary mandelic and phenylglyoxylic acids as indirect evaluation of styrene exposure

被引：25

作者：

Laffon, B

Lema, M

Méndez, J

机构：

[1] Univ A Coruna, Fac Ciencias, Dept Biol Celular & Mol, La Coruna 15071, Spain

[2] Univ A Coruna, Serv Gen Apoyo Invest, La Coruna, Spain

来源：

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | 2001年 / 753卷 / 02期

关键词：

mandelic acid; phenylglyoxylic acid; styrene; HPLC; urine;

D O I：

10.1016/S0378-4347(00)00583-1

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Styrene is rapidly metabolised to mandelic acid (MA) and phenylglyoxylic acid (PGA), which are excreted in urine. In this work, we have developed a simple, sensitive and specific high-performance liquid chromatographic method with minor sample preparation procedures for the simultaneous determination of MA and PGA in urine of workers exposed to styrene, Moreover, urine samples from workers of two plastic factories were analysed, styrene exposure levels of the workers were estimated and data obtained from the two factories were compared. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：385 / 393

页数：9

共 31 条

[21] STYRENE PRODUCTION, USE, AND HUMAN EXPOSURE [J].