Differentiation of cfiA-Negative and cfiA-Positive Bacteroides fragilis Isolates by Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry

被引：76

作者：

Wybo, Ingrid ^{[1
]}

De Bel, Annelies ^{[1
]}

Soetens, Oriane ^{[1
]}

Echahidi, Fedoua ^{[1
]}

Vandoorslaer, Kristof ^{[1
]}

Van Cauwenbergh, Marina ^{[1
]}

Pierard, Denis ^{[1
]}

机构：

[1] Vrije Univ Brussel, Univ Ziekenhuis Brussel, Dept Microbiol & Infect Control, B-1090 Brussels, Belgium

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2011年 / 49卷 / 05期

关键词：

CARBAPENEMASE GENE CFIA; ANTIBIOTIC SUSCEPTIBILITY; IDENTIFICATION; RESISTANCE; STRAINS; REVOLUTION; BACTERIA; HUNGARY; CEPA;

D O I：

10.1128/JCM.02321-10

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学];

摘要：

Carbapenem resistance in Bacteroides fragilis is associated with cfiA-encoded class B metallo-beta-lactamase. cfiA-negative and cfiA-positive isolates belong to genotypically distinct groups. Of a total of 248 B. fragilis isolates included in this study, 214 were susceptible, 10 were intermediate, and 24 were resistant to meropenem. We show that matrix-assisted laser desorption ionization-time of flight mass spectrometry is able to differentiate between cfiA-negative and cfiA-positive isolates and predict carbapenem resistance in a routine laboratory setting.

引用

页码：1961 / 1964

页数：4

共 21 条

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