Facile synthesis of puromycin-tethered oligonucleotides at the 3′-end

被引：11

作者：

Ikeda, S

Saito, I ^{[1
]}

Sugiyama, H

机构：

[1] Kyoto Univ, Fac Engn, Dept Synthet & Biol Chem, Kyoto 6068501, Japan

[2] Tokyo Med & Dent Univ, Inst Med & Dent Engn, Tokyo 1010062, Japan

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 33期

关键词：

D O I：

10.1016/S0040-4039(98)01226-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile method for the synthesis of puromycin-tethered oligonucleotides at the 3'-end is described. The method utilizes a novel CPG support derived from commercially available puromycin. Puromycin-tethered DNA and RNA oligomers were synthesized using a puromycin-tethered CPG support by the usual protocol for automated DNA and RNA synthesis. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：5975 / 5978

页数：4

共 15 条

[1] AN IMPROVED PROCEDURE FOR DERIVATIZATION OF CONTROLLED-PORE GLASS-BEADS FOR SOLID-PHASE OLIGONUCLEOTIDE SYNTHESIS [J].