Induction of lamina propria Th17 cells by intestinal commensal bacteria

被引：31

作者：

Atarashi, Koji ^{[1
,2
]}

Tanoue, Takeshi ^{[1
,2
]}

Honda, Kenya ^{[1
,2
,3
]}

机构：

[1] Univ Tokyo, Dept Immunol, Grad Sch Med, Tokyo 1130033, Japan

[2] Osaka Univ, Grad Sch Med, Lab Immune Regulat, Suita, Osaka 5650871, Japan

[3] Japan Sci & Technol Agcy, Precursory Res Embryon Sci & Technol PRESTO, Kawaguchi, Saitama 3320012, Japan

来源：

VACCINE | 2010年 / 28卷 / 50期

关键词：

Th17; Intestine; Lamina propria; Commensal bacteria; Mucosa; REGULATORY T-CELLS; TGF-BETA; HOST-DEFENSE; P2X RECEPTORS; HELPER-CELLS; DIFFERENTIATION; T(H)17; RESPONSES; ATP; IL-17;

D O I：

10.1016/j.vaccine.2010.09.026

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Th17 cells constitute a subset of activated CD4(+) T cells, characterized by their production of interleukin (IL)-17, IL-17F, and IL-22, that play a critical role in host defence against extracellular pathogens. An intriguing feature of these cells is their selective and constitutive presence in the intestinal lamina propria. The development of intestinal Th17 cells is controlled by intestinal commensal bacteria. Recently, segmented filamentous bacterium (SFB) was identified as a specific bacterial taxon that promotes Th17 differentiation in the small intestine of mice. We discuss the recent advances in our understanding of the mechanism of intestinal Th17 synthesis and its potential implications for the treatment of inflammatory bowel diseases. (c) 2010 Elsevier Ltd. All rights reserved.

引用

页码：8036 / 8038

页数：3

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