Connections between mRNA 3′ end processing and transcription termination

被引:148
作者
Buratowski, S [1 ]
机构
[1] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA
关键词
D O I
10.1016/j.ceb.2005.04.003
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Discoveries within the last few years have revealed that the multiple steps in gene expression are remarkably integrated. There have recently been several advances in deciphering how mRNA 3' end processing is linked with transcription elongation and termination. It has been known for quite a long time that transcription termination is somehow intertwined with polyadenylation, but it is still unclear exactly how these two processes influence each other. Some recent reports are shedding light on these connections.
引用
收藏
页码:257 / 261
页数:5
相关论文
共 36 条
[1]   Phosphorylation of serine 2 within the RNA polymerase IIC-terminal domain couples transcription and 3′ end processing [J].
Ahn, SH ;
Kim, M ;
Buratowski, S .
MOLECULAR CELL, 2004, 13 (01) :67-76
[2]   The CTD code [J].
Buratowski, S .
NATURE STRUCTURAL BIOLOGY, 2003, 10 (09) :679-680
[3]   Strange bedfellows: polyadenylation factors at the promoter [J].
Calvo, O ;
Manley, JL .
GENES & DEVELOPMENT, 2003, 17 (11) :1321-1327
[4]   RNA polymerase II accumulation in the promoter-proximal region of the dihydrofolate reductase and γ-actin genes [J].
Cheng, CH ;
Sharp, PA .
MOLECULAR AND CELLULAR BIOLOGY, 2003, 23 (06) :1961-1967
[5]   A FUNCTIONAL MESSENGER-RNA POLYADENYLATION SIGNAL IS REQUIRED FOR TRANSCRIPTION TERMINATION BY RNA POLYMERASE-II [J].
CONNELLY, S ;
MANLEY, JL .
GENES & DEVELOPMENT, 1988, 2 (04) :440-452
[6]   A role for SSU72 in balancing RNA polymerase II transcription elongation and termination [J].
Dichtl, B ;
Blank, D ;
Ohnacker, M ;
Friedlein, A ;
Roeder, D ;
Langen, H ;
Keller, W .
MOLECULAR CELL, 2002, 10 (05) :1139-1150
[7]   Functional interactions between the transcription and mRNA 3′ end processing machineries mediated by Ssu72 and Sub1 [J].
He, XY ;
Khan, AU ;
Cheng, HL ;
Pappas, DL ;
Hampsey, M ;
Moore, CL .
GENES & DEVELOPMENT, 2003, 17 (08) :1030-1042
[8]   Involvement of transcription termination factor 2 in mitotic repression of transcription elongation [J].
Jiang, Y ;
Liu, MY ;
Spencer, CA ;
Price, DH .
MOLECULAR CELL, 2004, 14 (03) :375-385
[9]   C-terminal repeat domain kinase I phosphorylates Ser2 and Ser5 of RNA polymerase IIC-terminal domain repeats [J].
Jones, JC ;
Phatnani, HP ;
Haystead, TA ;
MacDonald, JA ;
Alam, SM ;
Greenleaf, AL .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (24) :24957-24964
[10]   Transitions in RNA polymerase II elongation complexes at the 3′ ends of genes [J].
Kim, M ;
Ahn, SH ;
Krogan, NJ ;
Greenblatt, JF ;
Buratowski, S .
EMBO JOURNAL, 2004, 23 (02) :354-364