Genetic Analysis of Pathways to Parkinson Disease

被引：209

作者：

Hardy, John ^{[1
,2
]}

机构：

[1] UCL Inst Neurol, Reta Llla Weston Labs, London WC1N 3BG, England

[2] UCL Inst Neurol, Dept Mol Neurosci, London WC1N 3BG, England

来源：

NEURON | 2010年 / 68卷 / 02期

关键词：

GENOME-WIDE ASSOCIATION; ALZHEIMERS-DISEASE; NEURODEGENERATIVE DISEASE; MITOCHONDRIAL DYSFUNCTION; IDENTIFIES VARIANTS; PINK1; MUTATIONS; LRRK2; G2019S; LEWY BODIES; PATHOLOGY; DROSOPHILA-PINK1;

D O I：

10.1016/j.neuron.2010.10.014

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In this review I outline the arguments as to whether we should consider Parkinson disease one or more than one entity and discuss genetic findings from Mendelian and whole-genome association analysis in that context. I discuss what the demonstration of disease spread implies for our analysis of the genetic and epidemiologic risk factors for disease and outline the surprising fact that we now have genetically identified on the order of half our risk for developing the disease.

引用

页码：201 / 206

页数：6

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