Anti-brain but not celiac disease antibodies in Landau-Kleffner Syndrome and related epilepsies

被引：21

作者：

Boscolo, S

Baldas, V

Gobbi, G

Giordano, L

Cioni, G

Not, T

Ventura, A

Tongiorgi, E

机构：

[1] Univ Trieste, Dept Biol, BRAIN Ctr Neurosci, I-34127 Trieste, Italy

[2] IRCCS Burlo Garofolo, Pediat Clin, Trieste, Italy

[3] IRCCS Burlo Garofolo, Transfus Ctr, Trieste, Italy

[4] Osped Maggiore Bologna, Dept Materno Infantile, UONPI, Bologna, Italy

[5] Neurol Pediat Clin, Brescia, Italy

[6] Univ Pisa, Dept Dev Neurosci, Stella Maris Sci Inst, Pisa, Italy

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2005年 / 160卷 / 1-2期

关键词：

autounmunity; pediatric epilepsy; anti-brain autoantibodies;

D O I：

10.1016/j.jneuroim.2004.10.031

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The Landau-Kleffner syndrome, the continuous spikes-waves during slow sleep syndrome and the benign epilepsy of childhood with rolandic spikes are rare childhood epilepsies with unknown etiology. Improvement in patients treated with immunoglobulin suggests an involvement of the immune system. We provide immunohistochemical evidence of autoantibodies against rat brain auditory cortex, brainstem and cerebellum, in children suffering with one or more of these syndromes. Only 1/14 patient was celiac. (c) 2004 Elsevier B.V. All rights reserved.

引用

页码：228 / 232

页数：5

共 12 条

[1] PROPOSAL FOR REVISED CLASSIFICATION OF EPILEPSIES AND EPILEPTIC SYNDROMES [J].