Bilirubin removal from albumin - containing solution by adsorption on polymer resin

被引：18

作者：

Annesini, MC ^{[1
]}

Di Paola, L ^{[1
]}

Marrelli, L ^{[1
]}

Piemonte, V ^{[1
]}

Turchetti, L ^{[1
]}

机构：

[1] Univ Roma La Sapienza, Dept Chem Engn, I-00184 Rome, Italy

来源：

INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS | 2005年 / 28卷 / 07期

关键词：

bilirubin; albumin; adsorption;

D O I：

10.1177/039139880502800707

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Adsorption equilibrium of bilirubin onto polymeric resins is studied. Solutions containing albumin are used in order to simulate the behavior of systems for removal of albumin-bound substances from blood, serum or dialysis fluids. The effect of albumin pre-loading on the resin is also analysed. Results are explained by a chemically based model that accounts for binding reaction between albumin and bilirubin in the liquid phase. Thermodynamic equilibria and physical models are essential tools for designing adsorption columns aimed at detoxification treatments.

引用

页码：686 / 693

页数：8

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