Neurodegenerative Pathways in Parkinson's Disease: Therapeutic Strategies

被引：47

作者：

Cardoso, S. M. ^{[1
,2
]}

Moreira, P., I

Agostinho, P.

Pereira, C.

Oliveira, C. R.

机构：

[1] Univ Coimbra, Fac Med Coimbra, Ctr Neurosci & Cell Biol, P-3004504 Coimbra, Portugal

[2] Univ Coimbra, Fac Med Coimbra, Inst Biochem, P-3004504 Coimbra, Portugal

来源：

CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS | 2005年 / 4卷 / 04期

关键词：

alpha-synuclein; neuronal circuits; oxidative stress; mitochondria; proteasome; neuroinflammation; cell death; therapeutics;

D O I：

10.2174/1568007054546072

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Parkinson's disease (PD), considered one of the major neurological disorders, is characterized by the loss of dopaminergic neurons in the pars compacta of the substantia nigra and by the presence of intraneuronal cytoplasmic inclusions called Lewy bodies. The causes for degeneration of PD neurons remain unclear, however, recent findings contributed to clarify this issue. This review will discuss the current understanding of the mechanisms underlying Parkinson's disease pathogenesis, focusing on the current and potential therapeutic strategies for human treatment.

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收藏

页码：405 / 419

页数：15

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