The trans-labilization of nitric oxide in RuII complexes by C-bound imidazoles

被引：58

作者：

Lopes, LGF ^{[1
]}

Wieraszko, A

El-Sherif, Y

Clarke, MJ

机构：

[1] Boston Coll, Merkert Chem Ctr, Chestnut Hill, MA 02467 USA

[2] Univ Fed Ceara, Dept Quim Organ & Inorgan, BR-60451970 Fortaleza, Ceara, Brazil

[3] CUNY Coll Staten Isl, Grad Ctr, Ctr Dev Neurosci, Dept Biol, Staten Isl, NY 10314 USA

来源：

INORGANICA CHIMICA ACTA | 2001年 / 312卷 / 1-2期

基金：

美国国家卫生研究院;

关键词：

ruthenium; nitric oxide; imidazole; long term potentiation;

D O I：

10.1016/S0020-1693(00)00341-8

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The synthesis, characterization and reactivity of trans-[NO(L)(NH3)(4)Ru]Cl-3 (L = imidazole, theophylline and caffeine) are presented. H-1 NMR spectroscopy indicates that the imidazole ligands are coordinated to the Ru-II through a carbon atom (im kappa (2) 1,3Me(2)Xan kappa (8) and 1,3,7Me(3)Xan kappa (8)). The nitrosyl stretching frequencies (v(NO) congruent to 1913 cm(-1)) suggest the coordinated nitrosyl has substantial NO+ character. The complexes undergo a single-electron reduction (E-degrees congruent to - 0.50 V versus Ag/AgCl), which involves the coordinated nitrosyl. Dissociation of NO. in the reduced species is facilitated by the trans-imidazolylidene ligand. The lower than expected reduction potentials of these complexes may account for their inactivity in evoking neuronal firing in the hippocampus by releasing NO following reduction. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：15 / 22

页数：8

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