Mechanistically diverse enzyme superfamilies: the importance of chemistry in the evolution of catalysis

被引：91

作者：

Gerlt, JA ^{[1
]}

Babbitt, PC

机构：

[1] Univ Illinois, Dept Biochem, Urbana, IL 61801 USA

[2] Univ Calif San Francisco, Dept Biopharmaceut Sci, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94143 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 1998年 / 2卷 / 05期

关键词：

D O I：

10.1016/S1367-5931(98)80091-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The strategy that nature has used to evolve new catalytic activities from pre-existing enzymes (i.e. retention of substrate binding or of catalytic mechanism) has been controversial. Recent work supports a strategy in which a partial reaction, catalyzed by a progenitor, is retained, and the active-site architecture is modified to allow the intermediate generated to be directed to different products.

引用

页码：607 / 612

页数：6

共 40 条

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