PARP goes transcription

被引：468

作者：

Kraus, WL

Lis, JT ^{[1
]}

机构：

[1] Cornell Univ, Dept Mol Biol & Genet, Ithaca, NY 14853 USA

[2] Cornell Univ, Weill Med Coll, Dept Pharmacol, New York, NY 10021 USA

来源：

CELL | 2003年 / 113卷 / 06期

关键词：

POLY(ADP-RIBOSE) POLYMERASE BINDS; GENE-EXPRESSION; DEPENDENT TRANSCRIPTION; CHROMATIN STRUCTURE; COACTIVATOR; PROMOTER; NUCLEOSOME;

D O I：

10.1016/S0092-8674(03)00433-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

PARP-1, an enzyme that catalyzes the attachment of ADP ribose units to target proteins, plays at least two important roles in transcription regulation. First, PARP-1 modifies histones and creates an anionic poly(ADPribose) matrix that binds histones, thereby promoting the decondensation of higher-order chromatin structures. Second, PARP-1 acts as a component of enhancer/promoter regulatory complexes. Recent studies have shown that both of these activities are critical for gene regulation in vivo.

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页码：677 / 683

页数：7

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