PARP-1, an enzyme that catalyzes the attachment of ADP ribose units to target proteins, plays at least two important roles in transcription regulation. First, PARP-1 modifies histones and creates an anionic poly(ADPribose) matrix that binds histones, thereby promoting the decondensation of higher-order chromatin structures. Second, PARP-1 acts as a component of enhancer/promoter regulatory complexes. Recent studies have shown that both of these activities are critical for gene regulation in vivo.
机构:
Carnegie Inst Sci, Dept Embryol, Howard Hughes Med Res Labs, Baltimore, MD 21210 USACarnegie Inst Sci, Dept Embryol, Howard Hughes Med Res Labs, Baltimore, MD 21210 USA
Tulin, A
;
Spradling, A
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机构:
Carnegie Inst Sci, Dept Embryol, Howard Hughes Med Res Labs, Baltimore, MD 21210 USACarnegie Inst Sci, Dept Embryol, Howard Hughes Med Res Labs, Baltimore, MD 21210 USA
机构:
Carnegie Inst Sci, Howard Hughes Med Res Labs, Dept Embryol, Baltimore, MD 21210 USACarnegie Inst Sci, Howard Hughes Med Res Labs, Dept Embryol, Baltimore, MD 21210 USA
Tulin, A
;
Stewart, D
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机构:
Carnegie Inst Sci, Howard Hughes Med Res Labs, Dept Embryol, Baltimore, MD 21210 USACarnegie Inst Sci, Howard Hughes Med Res Labs, Dept Embryol, Baltimore, MD 21210 USA
Stewart, D
;
Spradling, AC
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机构:
Carnegie Inst Sci, Howard Hughes Med Res Labs, Dept Embryol, Baltimore, MD 21210 USACarnegie Inst Sci, Howard Hughes Med Res Labs, Dept Embryol, Baltimore, MD 21210 USA
机构:
Carnegie Inst Sci, Dept Embryol, Howard Hughes Med Res Labs, Baltimore, MD 21210 USACarnegie Inst Sci, Dept Embryol, Howard Hughes Med Res Labs, Baltimore, MD 21210 USA
Tulin, A
;
Spradling, A
论文数: 0引用数: 0
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机构:
Carnegie Inst Sci, Dept Embryol, Howard Hughes Med Res Labs, Baltimore, MD 21210 USACarnegie Inst Sci, Dept Embryol, Howard Hughes Med Res Labs, Baltimore, MD 21210 USA
机构:
Carnegie Inst Sci, Howard Hughes Med Res Labs, Dept Embryol, Baltimore, MD 21210 USACarnegie Inst Sci, Howard Hughes Med Res Labs, Dept Embryol, Baltimore, MD 21210 USA
Tulin, A
;
Stewart, D
论文数: 0引用数: 0
h-index: 0
机构:
Carnegie Inst Sci, Howard Hughes Med Res Labs, Dept Embryol, Baltimore, MD 21210 USACarnegie Inst Sci, Howard Hughes Med Res Labs, Dept Embryol, Baltimore, MD 21210 USA
Stewart, D
;
Spradling, AC
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h-index: 0
机构:
Carnegie Inst Sci, Howard Hughes Med Res Labs, Dept Embryol, Baltimore, MD 21210 USACarnegie Inst Sci, Howard Hughes Med Res Labs, Dept Embryol, Baltimore, MD 21210 USA