PARP goes transcription

被引:468
作者
Kraus, WL
Lis, JT [1 ]
机构
[1] Cornell Univ, Dept Mol Biol & Genet, Ithaca, NY 14853 USA
[2] Cornell Univ, Weill Med Coll, Dept Pharmacol, New York, NY 10021 USA
关键词
POLY(ADP-RIBOSE) POLYMERASE BINDS; GENE-EXPRESSION; DEPENDENT TRANSCRIPTION; CHROMATIN STRUCTURE; COACTIVATOR; PROMOTER; NUCLEOSOME;
D O I
10.1016/S0092-8674(03)00433-1
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
PARP-1, an enzyme that catalyzes the attachment of ADP ribose units to target proteins, plays at least two important roles in transcription regulation. First, PARP-1 modifies histones and creates an anionic poly(ADPribose) matrix that binds histones, thereby promoting the decondensation of higher-order chromatin structures. Second, PARP-1 acts as a component of enhancer/promoter regulatory complexes. Recent studies have shown that both of these activities are critical for gene regulation in vivo.
引用
收藏
页码:677 / 683
页数:7
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