Gene expression of the P2X receptors in the rat retina

被引：57

作者：

Brändle, U

Guenther, E

Irrle, C

Wheeler-Schilling, TH

机构：

[1] Univ Tubingen, Hosp Eye, Dept Pathophysiol Vis & Neuroophthalmol, Div Expt Ophthalmol, D-72076 Tubingen, Germany

[2] Univ Tubingen, Dept Otolaryngol, D-72076 Tubingen, Germany

来源：

MOLECULAR BRAIN RESEARCH | 1998年 / 59卷 / 02期

关键词：

P2X receptor; rat; retina; choroid; RT-PCR;

D O I：

10.1016/S0169-328X(98)00159-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Molecular-biological methods were used to demonstrate the expression of six P2X receptor subunits (P2X(1)-P2X(6)) in retina and choroid. Despite the considerable evidence for signalling by extracellular nucleotides in other sensory systems, few studies have been undertaken in the eye. RT-PCR for the detection of P2X subunit mRNA in the rat of different postnatal developmental stages (P23-P210) revealed the presence of P2X(2) and P2X(4) mRNA in the retina and choroid; P2X(3), and P2X(5) were detected only in the retina. There was no evidence for P2X(1) and P2X(6) mRNA in the ocular tissue under investigation. Our data suggest that extracellular ATP may have influences on visual processing. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：269 / 272

页数：4

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