The role of long non-coding RNAs in chromatin structure and gene regulation: variations on a theme

被引：56

作者：

Umlauf, David ^{[1
]}

Fraser, Peter ^{[1
]}

Nagano, Takashi ^{[1
]}

机构：

[1] Babraham Inst, Lab Chromatin & Gene Express, Cambridge CB22 3AT, England

来源：

BIOLOGICAL CHEMISTRY | 2008年 / 389卷 / 04期

基金：

英国生物技术与生命科学研究理事会; 英国医学研究理事会;

关键词：

histone modifications; nuclear organization; transcription; transcription factories;

D O I：

10.1515/BC.2008.047

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Transcriptome studies have uncovered a plethora of non-coding RNAs (ncRNA) in mammals. Most originate within intergenic regions of the genome and recent evidence indicates that some are involved in many different pathways that ultimately act on genome architecture and gene expression. In this review, we discuss the role of well-characterized long ncRNAs in gene regulation pointing to their similarities, but also their differences. We will attempt to highlight a paradoxical situation in which transcription is needed to repress entire chromosomal domains possibly through the action of ncRNAs that create nuclear environments refractory to transcription.

引用

页码：323 / 331

页数：9

共 59 条

[1] Chromodomains are protein-RNA interaction modules [J].

Akhtar, A ;

Zink, D ;

Becker, PB .

NATURE, 2000, 407 (6802) :405-409

[2] X-chromosome inactivation: Counting, choice and initiation [J].

Avner, P ;

Heard, E .

NATURE REVIEWS GENETICS, 2001, 2 (01) :59-67

[3]

Bacher CP, 2006, NAT CELL BIOL, V8, P293, DOI 10.1038/ncb1365

[4] Spatial distribution of di- and tri-methyl lysine 36 of histone H3 at active genes [J].

Bannister, AJ ;

Schneider, R ;

Myers, FA ;

Thorne, AW ;

Crane-Robinson, C ;

Kouzarides, T .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (18) :17732-17736

[5] Genomic maps and comparative analysis of histone modifications in human and mouse [J].

Bernstein, BE ;

Kamal, M ;

Lindblad-Toh, K ;

Bekiranov, S ;

Bailey, DK ;

Huebert, DJ ;

McMahon, S ;

Karlsson, EK ;

Kulbokas, EJ ;

Gingeras, TR ;

Schreiber, SL ;

Lander, ES .

CELL, 2005, 120 (02) :169-181

[6] Mouse polycomb proteins bind differentially to methylated histone H3 and RNA and are enriched in facultative heterochromatin [J].

Bernstein, E ;

Duncan, EM ;

Masui, O ;

Gil, J ;

Heard, E ;

Allis, CD .

MOLECULAR AND CELLULAR BIOLOGY, 2006, 26 (07) :2560-2569

[7] Role of histone H3 lysine 27 methylation in polycomb-group silencing [J].

Cao, R ;

Wang, LJ ;

Wang, HB ;

Xia, L ;

Erdjument-Bromage, H ;

Tempst, P ;

Jones, RS ;

Zhang, Y .

SCIENCE, 2002, 298 (5595) :1039-1043

[8] Long-range chromatin regulatory interactions in vivo [J].

Carter, D ;

Chakalova, L ;

Osborne, CS ;

Dai, YF ;

Fraser, P .

NATURE GENETICS, 2002, 32 (04) :623-626

[9] A novel role for Xist RNA in the formation of a repressive nuclear compartment into which genes are recruited when silenced [J].

Chaumeil, Julie ;

Le Baccon, Patricia ;

Wutz, Anton ;

Heard, Edith .

GENES & DEVELOPMENT, 2006, 20 (16) :2223-2237

[10] Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution [J].

Cheng, J ;

Kapranov, P ;

Drenkow, J ;

Dike, S ;

Brubaker, S ;

Patel, S ;

Long, J ;

Stern, D ;

Tammana, H ;

Helt, G ;

Sementchenko, V ;

Piccolboni, A ;

Bekiranov, S ;

Bailey, DK ;

Ganesh, M ;

Ghosh, S ;

Bell, I ;

Gerhard, DS ;

Gingeras, TR .

SCIENCE, 2005, 308 (5725) :1149-1154

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