Trim family proteins:: Retroviral restriction and antiviral defence

被引:618
作者
Nisole, S
Stoye, JP
Saïb, A
机构
[1] Univ Paris 07, UMR 7151, CNRS, Hop St Louis, F-75475 Paris, France
[2] Natl Inst Med Res, Div Virol, London NW7 1AA, England
基金
英国医学研究理事会;
关键词
D O I
10.1038/nrmicro1248
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Members of the tripartite motif ( TRIM) protein family are involved in various cellular processes, including cell proliferation, differentiation, development, oncogenesis and apoptosis. Some TRIM proteins display antiviral properties, targeting retroviruses in particular. The potential activity of TRIM19, better known as promyelocytic leukaemia protein, against several viruses has been well documented and, recently, TRIM5 alpha has been identified as the factor responsible for the previously described Lv1 and Ref1 antiretroviral activities. There is also evidence indicating that other TRIM proteins can influence viral replication. These findings are reviewed here, and the possibility that TRIMs represent a new and widespread class of antiviral proteins involved in innate immunity is also considered.
引用
收藏
页码:799 / 808
页数:10
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