Design and synthesis of a chiral N-tethered bis(imidazoline) ligand

被引：27

作者：

Arai, T ^{[1
]}

Mizukami, T

Yokoyama, N

Nakazato, D

Yanagisawa, A

机构：

[1] Chiba Univ, Fac Sci, Dept Chem, Inage 2638522, Japan

[2] Chiba Univ, Grad Sch Sci & Technol, Inage 2638522, Japan

来源：

SYNLETT | 2005年 / 17期

关键词：

asymmetric catalysis; ligands; imidazoline; copper; cyclopropanation;

D O I：

10.1055/s-2005-917101

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A chiral nitrogen-tethered bis (imidazoline) ligand (Nb-imidazoline) was newly designed and synthesized in a divergent strategy. Thus, a single coupling reaction of primary amine with two molecules of chloromethylated imidazoline provided the Nb-imidazoline. The copper(II) triflate complex of Nb-imidazoline catalyzed a trans-selective cyclopropanation of styrene with ethyl diazoacetate to give the adduct in high chemical yield with good enantiomeric excess up to 83%.

引用

页码：2670 / 2672

页数：3

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