The endocannabinoid system in cancer - Potential therapeutic target?

被引：53

作者：

Flygare, Jenny

Sander, Birgitta ^{[1
]}

机构：

[1] Karolinska Inst, Dept Lab Med, Div Pathol, SE-14186 Stockholm, Sweden

来源：

SEMINARS IN CANCER BIOLOGY | 2008年 / 18卷 / 03期

关键词：

endocannabinoid; cannabinoid; cancer; lymphoma;

D O I：

10.1016/j.semcancer.2007.12.008

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Endogenous arachidonic acid metabolites with properties similar to compounds of Cannabis sativa Linnaeus, the so-called endocannabinoids, have effects on various types of cancer. Although endocannabinoids and synthetic cannabinoids may have pro-proliferative effects, predominantly inhibitory effects on tumor growth, angiogenesis, migration and metastasis have been described. Remarkably, these effects may be selective for the cancer cells, while normal cells and tissues are spared. Such apparent tumor cell selectivity makes the endocannabinoid system an attractive potential target for cancer therapy. In this review we discuss various means by which the endocannabinoid system may be targeted in cancer and the current knowledge considering the regulation of the endocannabinoid system in malignancy. (C) 2007 Elsevier Ltd. All rights reserved.

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页码：176 / 189

页数：14

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