The endocannabinoid system in cancer - Potential therapeutic target?

被引：53

作者：

Flygare, Jenny

Sander, Birgitta ^{[1
]}

机构：

[1] Karolinska Inst, Dept Lab Med, Div Pathol, SE-14186 Stockholm, Sweden

来源：

SEMINARS IN CANCER BIOLOGY | 2008年 / 18卷 / 03期

关键词：

endocannabinoid; cannabinoid; cancer; lymphoma;

D O I：

10.1016/j.semcancer.2007.12.008

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Endogenous arachidonic acid metabolites with properties similar to compounds of Cannabis sativa Linnaeus, the so-called endocannabinoids, have effects on various types of cancer. Although endocannabinoids and synthetic cannabinoids may have pro-proliferative effects, predominantly inhibitory effects on tumor growth, angiogenesis, migration and metastasis have been described. Remarkably, these effects may be selective for the cancer cells, while normal cells and tissues are spared. Such apparent tumor cell selectivity makes the endocannabinoid system an attractive potential target for cancer therapy. In this review we discuss various means by which the endocannabinoid system may be targeted in cancer and the current knowledge considering the regulation of the endocannabinoid system in malignancy. (C) 2007 Elsevier Ltd. All rights reserved.

引用

收藏

页码：176 / 189

页数：14

相关论文

共 132 条

[61]

Jacobsson SOP, 2001, J PHARMACOL EXP THER, V299, P951

[62] Enzyme activity profiles of the secreted and membrane proteome that depict cancer cell invasiveness [J].

Jessani, N ;

Liu, YS ;

Humphrey, M ;

Cravatt, BF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (16) :10335-10340

[63] Δ9-tetrahydrocannabinol-induced apoptosis in Jurkat leukemia T cell's is regulated by translocation of bad to mitochondria [J].

Jia, Wentao ;

Hegde, Venkatesh L. ;

Singh, Narendra P. ;

Sisco, Daniel ;

Grant, Steven ;

Nagarkatti, Mitzi ;

Nagarkatti, Prakash S. .

MOLECULAR CANCER RESEARCH, 2006, 4 (08) :549-562

[64] The endocannabinoid system: Current pharmacological research and therapeutic possibilities [J].

Jonsson, KO ;

Holt, S ;

Fowler, CJ .

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2006, 98 (02) :124-134

[65] The peripheral cannabinoid receptor Cb2, frequently expressed on AML blasts, either induces a neutrophilic differentiation block or confers abnormal migration properties in a ligand-dependent manner [J].

Jordà, MA ;

Rayman, N ;

Tas, M ;

Verbakel, SE ;

Battista, N ;

van Lom, K ;

Löwenberg, B ;

Maccarrone, M ;

Delwel, R .

BLOOD, 2004, 104 (02) :526-534

[66] The peripheral cannabinoid receptor Cb2, a novel oncoprotein, induces a reversible block in neutrophilic differentiation [J].

Jordà, MA ;

Löwenberg, B ;

Delwel, R .

BLOOD, 2003, 101 (04) :1336-1343

[67] Anandamide is an endogenous inhibitor for the migration of tumor cells and T lymphocytes [J].

Joseph, J ;

Niggemann, B ;

Zaenker, KS ;

Entschladen, F .

CANCER IMMUNOLOGY IMMUNOTHERAPY, 2004, 53 (08) :723-728

[68]

KAMINSKI NE, 1992, MOL PHARMACOL, V42, P736

[69] The cannabinoid system and immune modulation [J].

Klein, TW ;

Newton, C ;

Larsen, K ;

Lu, L ;

Perkins, I ;

Nong, L ;

Friedman, H .

JOURNAL OF LEUKOCYTE BIOLOGY, 2003, 74 (04) :486-496

[70] Oxidative metabolism of endocannabinoids [J].

Kozak, KR ;

Marnett, LJ .

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, 2002, 66 (2-3) :211-220

← 2 3 4 5 6 7 8 9 10 11 →