Diversity, biogenesis and function of microbial amyloids

被引:256
作者
Blanco, Luz P. [1 ]
Evans, Margery L. [1 ]
Smith, Daniel R. [1 ]
Badtke, Matthew P. [1 ]
Chapman, Matthew R. [1 ]
机构
[1] Univ Michigan, Dept Mol Cellular & Dev Biol, Ann Arbor, MI 48109 USA
基金
美国国家卫生研究院;
关键词
ESCHERICHIA-COLI O157-H7; SCANNING-ELECTRON-MICROSCOPY; BACILLUS-SUBTILIS BIOFILMS; THIN AGGREGATIVE FIMBRIAE; ALBICANS ALS ADHESINS; MICROCIN E492; IN-VITRO; STREPTOMYCES-COELICOLOR; FORMING BACTERIOCIN; FIBER BIOGENESIS;
D O I
10.1016/j.tim.2011.11.005
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Amyloid is a distinct beta-sheet-rich fold that many proteins can acquire. Frequently associated with neurodegenerative diseases in humans, including Alzheimer's, Parkinson's and Huntington's diseases, amyloids are traditionally considered the product of protein misfolding. However, the amyloid fold is now recognized as a ubiquitous part of normal cellular biology. Functional amyloids have been identified in nearly all facets of cellular life, with microbial functional amyloids leading the way. Unlike disease-associated amyloids, functional amyloids are assembled by dedicated, directed pathways and ultimately perform a physiological function that benefits the organism. The evolved amyloid assembly and disassembly pathways of microbes have provided novel insights into how cells have harnessed the amyloid assembly process for productive means. An understanding of functional amyloid biogenesis promises to provide a fresh perspective on the molecular events that underlie disease-associated amyloidogenesis. Here, we review functional microbial amyloids with an emphasis on curli fibers and their role in promoting biofilm formation and other community behaviors.
引用
收藏
页码:66 / 73
页数:8
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