Efflux pump-mediated quinolone resistance in Staphylococcus aureus strains wild type for gyrA, gyrB, grlA, and norA

被引：39

作者：

Muñoz-Bellido, JL

Manzanares, MAA

Andrés, JAM

Zufiaurre, MNG

Ortiz, G

Hernández, MS

García-Rodríguez, JA

机构：

[1] Hosp Univ Salamanca, Dept Microbiol, Salamanca 37007, Spain

[2] Hosp Gen Univ, Fac Med, Dept Microbiol, Murcia, Spain

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1999年 / 43卷 / 02期

关键词：

D O I：

10.1128/AAC.43.2.354

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Fluoroquinolone efflux was studied in 47 Staphylococcus aureus clinical strains with MICs of ciprofloxacin (CFX) of less than or equal to 2 mu g/ml. Forty-three strains were wild type for gyrA, gyrB, and grlA quinolone resistance-determining regions and for norA and its promoter region. Forty of these strains (MICs of CFX, 0.1 to 0.2 mu g/ml) did not show efflux of fluoroquinolones. Three strains (MICs of CFS, 1 to 2 mu g/ml) showed efflux. These results suggest that efflux can appear in S. aureus clinical strains in the absence of mutations in norA and its promoter.

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页码：354 / 356

页数：3

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