Increased transcription of glutamate-aspartate transporter (GLAST/GluT-1) mRNA following kainic acid-induced limbic seizure

被引：38

作者：

Nonaka, M

Kohmura, E

Yamashita, T

Shimada, S

Tanaka, K

Yoshimine, T

Tohyama, M

Hayakawa, T

机构：

[1] Osaka Univ, Sch Med, Dept Neurosurg, Suita, Osaka 565, Japan

[2] Osaka Univ, Sch Med, Dept Anat & Neurosci, Suita, Osaka 565, Japan

[3] Natl Ctr Neurol & Psychiat, Natl Inst Neurosci, Dept Degenerat Neurol Dis, Kodaira, Tokyo 187, Japan

来源：

MOLECULAR BRAIN RESEARCH | 1998年 / 55卷 / 01期

关键词：

glutamate-aspartate transporter (GLAST/GluT-1); kainic acid; seizures; hippocampus;

D O I：

10.1016/S0169-328X(97)00361-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Expression of mRNA for glutamate-aspartate transporter (GLAST/GluT-1/EAAT1) was studied in the brain of the rat which presented recurrent limbic seizure following systemic administration of kainic acid (KA) by in situ hybridization and Northern blot analysis. The expression of GLAST mRNA was markedly increased after 12 h and peaked after 48 h in animals which demonstrated limbic seizure. The induction of the mRNA were observed in the small non-neuronal cells in the hippocampus, especially around CA3 region and hilus. In contrast, there was no change in GLAST mRNA levels in KA injected seizure-free animals. These findings suggest that GLAST mRNA is induced by seizure and increased extracelluar glutamate levels during seizure may be important for induction of GLAST mRNA. (C) 1998 Elsevier Science.

引用

页码：54 / 60

页数：7

共 33 条

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