Stereocontrol in the addition of allyl metal reagents to an optically active imine derived from malic acid, leading to a formal synthesis of (+)-negamycin

被引：14

作者：

Shimizu, M ^{[1
]}

Morita, A ^{[1
]}

Fujisawa, T ^{[1
]}

机构：

[1] Mie Univ, Dept Chem Mat, Tsu, Mie 5148507, Japan

来源：

CHEMISTRY LETTERS | 1998年 / 05期

关键词：

D O I：

10.1246/cl.1998.467

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Complete anti-stereoselection has been achieved on the addition of allyl metal reagents to an optically active imine derived from malic acid. The homoallyl amine thus obtained was converted into the known intermediate for the synthesis of (+)-Negamycin in enantiomerically pure form.

引用

页码：467 / 468

页数：2

共 23 条

[21] STEREOCONTROLLED SYNTHESIS OF (+)-NEGAMYCIN FROM AN ACYCLIC HOMOALLYLAMINE BY 1,3-ASYMMETRIC INDUCTION [J].