Xanthofulvin, a novel semaphorin inhibitor produced by a strain of Penicillium

被引：42

作者：

Kumagai, K

Hosotani, N

Kikuchi, K

Kimura, T

Saji, I

机构：

[1] Sumitomo Pharmaceut Co Ltd, Div Res, Exploratory Res Grp, Takarazuka, Hyogo 6650051, Japan

[2] Sumitomo Pharmaceut Co Ltd, Genomic Sci Labs, Div Res, Osaka 5540022, Japan

来源：

JOURNAL OF ANTIBIOTICS | 2003年 / 56卷 / 07期

关键词：

D O I：

10.7164/antibiotics.56.610

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A new semaphorin inhibitor xanthofulvin was isolated from the cultured broth of a fungus Penicillium sp. SPF-3059 along with a known compound vinaxanthone by solvent extraction and bioassay-guided fractionation. The tautomeric structure of xanthofulvin was determined by spectroscopic analyses. The two compounds exhibited significant semaphorin inhibitory activity with IC50 values of 0.09 and 0.1 mug/ml, respectively, in semaphorin3A-induced growth cone collapse assay using cultured chick dorsal root ganglia neurons.

引用

页码：610 / 616

页数：7

共 16 条

[1] STRUCTURE OF A NOVEL PHOSPHOLIPASE-C INHIBITOR, VINAXANTHONE (RO-09-1450), PRODUCED BY PENICILLIUM-VINACEUM [J].