Oxidative DNA damage mediated by metal-peptide complexes

被引：21

作者：

Burrows, CJ ^{[1
]}

Perez, RJ

Muller, JG

Rokita, SE

机构：

[1] Univ Utah, Dept Chem, Salt Lake City, UT 84112 USA

[2] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA

来源：

PURE AND APPLIED CHEMISTRY | 1998年 / 70卷 / 02期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1351/pac199870020275

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Peptides and proteins are able to form coordination complexes with nickel(II) and copper(ll) through ligation of deprotonated amide nitrogens, the amino terminus, and the side chains of such residues as histidine and the amino terminus. These complexes are reactive with either O-2 alone or O-2 in the presence of other oxidants or reductants to generate reactive intermediates capable of DNA damage. Both DNA strand scission and cross-linking have been observed.

引用

页码：275 / 278

页数：4

共 24 条

[1]

[Anonymous], BIOL INORGANIC COPPE

[2] DIOXYGEN-INDUCED DECARBOXYLATION AND HYDROXYLATION OF [NI-II(GLYCYL-GLYCYL-L-HISTIDINE)] OCCURS VIA NI-III - X-RAY CRYSTAL-STRUCTURE OF [NI-II(GLYCYL-GLYCYL-ALPHA-HYDROXY-D,L-HISTAMINE)]CENTER-DOT-3H2O [J].