NICKEL(III)-PROMOTED DNA CLEAVAGE WITH AMBIENT DIOXYGEN

被引：96

作者：

CHENG, CC ^{[1
]}

ROKITA, SE ^{[1
]}

BURROWS, CJ ^{[1
]}

机构：

[1] SUNY STONY BROOK,DEPT CHEM,STONY BROOK,NY 11794

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1993年 / 32卷 / 02期

关键词：

D O I：

10.1002/anie.199302771

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Oxygen-sensitive nickel(II) complexes with macrocyclic ligands promote DNA cleavage without additional oxidants, initiators, or irradiation. The reaction does not involve OH. radicals, but superoxido-Ni(III) complexes may play a role. The reactivity of the nickel complexes is highly dependent on the substituents on the ligands, which may allow fine-tuning for in vivo applications. R1,R2 e.g. F, H.

引用

页码：277 / 278

页数：2

共 18 条

[1] OXYGEN ACTIVATION WITH TRANSITION-METAL COMPLEXES - NICKEL-CATALYZED OXIDATION OF A PENTACOORDINATED SUBSTRATE
BERKESSEL, A
BATS, JW
SCHWARZ, C
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1990, 29 (01): : 106 - 108
[2] Berkessel A., 1990, ANGEW CHEM, V102, P81
[3] OXYGEN ACTIVATION ON NICKEL(II)TETRAHYDROSALEN COMPLEXES WITH THE FORMATION OF NICKEL(II)DIHYDROSALEN COMPLEXES
BOTTCHER, A
ELIAS, H
MULLER, L
PAULUS, H
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1992, 31 (05): : 623 - 625
[4] Bottcher A., 1992, ANGEW CHEM, V104, P635
[5] OXYGEN INSERTION IN THE NI(II) COMPLEXES OF DIOXOPENTAAZA MACROCYCLIC LIGANDS
CHEN, D
MARTELL, AE
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1990, 112 (25) : 9411 - 9412
[6] DIOXYGEN ADDUCTS OF NICKEL(II) AND COBALT(II) DIOXOPENTAAZAMACROCYCLIC COMPLEXES - KINETICS, STABILITIES, AND HYDROXYLATION OF THE LIGANDS IN THE NICKEL DIOXYGEN COMPLEXES
CHEN, D
MOTEKAITIS, RJ
MARTELL, AE
[J]. INORGANIC CHEMISTRY, 1991, 30 (06) : 1396 - 1402
[7] DNA MODIFICATION - INTRINSIC SELECTIVITY OF NICKEL(II) COMPLEXES
CHEN, XY
ROKITA, SE
BURROWS, CJ
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1991, 113 (15) : 5884 - 5886
[8] CONFORMATION-SPECIFIC DETECTION OF GUANINE IN DNA - ENDS, MISMATCHES, BULGES, AND LOOPS
CHEN, XY
BURROWS, CJ
ROKITA, SE
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1992, 114 (01) : 322 - 325
[9] DERVAN PB, 1991, METHOD ENZYMOL, V208, P497
[10] THE 1ST FLUORINATED CYCLAMS
KIMURA, E
SHIONOYA, M
OKAMOTO, M
NADA, H
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1988, 110 (11) : 3679 - 3680

← 1 2 →